What can result from a drug interaction with grapefruit juice?

The interaction of grapefruit juice with certain medications is well-documented and primarily involves the alteration of drug metabolism. Grapefruit juice can inhibit specific enzymes in the liver and intestines, particularly cytochrome P450 3A4 (CYP3A4). This inhibition can lead to higher concentrations of the medication in the bloodstream because the drug is not metabolized as quickly as it normally would be. This change can enhance the effects of the drug, potentially increasing the risk of side effects and toxicity.

In contrast, the other options describe effects that are not typically associated with grapefruit juice interactions. They either misrepresent how grapefruit juice works with medications or suggest a different interaction mechanism. Understanding the metabolic impact of grapefruit juice helps healthcare providers anticipate and manage potential drug interactions effectively, ensuring patient safety and medication efficacy.